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Start lean or get lean first with the assistance of medication, then build muscle from a favorable metabolic position while maintaining low body fat

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If slow titration does not work to minimize side effects, suggest small food portions and make sure any reflux symptoms are appropriately treated (a short course of a proton pump inhibitor is most commonly recommended) (Gorgojo-Martínez JJ et al, J Clin Med 2022;12(1):145)